A new treatment option has been recommended by Nice to help treat women with Endometriosis. This can be a painful and life-altering condition which causes tissue similar to the lining of the womb to grow in other areas of the body, such as the ovaries, fallopian tubes, bowels or bladder.
This can cause abdominal pain and a range of other symptoms. Find out more about Endometriosis and the currently available Treatments in our article.
The recent guidance that has been published by NICE is for a new hormonal therapy called Linzagolix. The treatment is aimed at adult women of reproductive age whose symptoms have not been successfully managed by other medical or surgical treatments. Currently, only women who have tried multiple other treatments will be offered the new therapy, which works to block the hormones which enable the unwanted tissue growth.
Linzagolix, also known as Yselty, will be available as a daily tablet a convenient way for women of working age to maintain their usual routines, whilst managing their condition. However, it cannot be used in conjunction with a hormonal contraceptive and may cause side effects such as mood swings or anxiety. Alternative therapies must also be sought at the earliest possibility if a woman becomes pregnant whilst taking Linzagolix.
According to Nice:
“In clinical trials, women taking Linzagolix with hormone therapy had significant reductions in both everyday pelvic pain and painful periods.”
The medicine was approved by the MHRA in March, 2025 and final guidance on Linzagolix is due to be published on 25 June. The NHS in England must then make the treatment available within 90 days – this means that Linzagolix could be available on the NHS from the end of September 2025.
What about other treatments for Endometriosis?
Because endometriosis is a condition which affects the reproductive organs, it can be more tricky to treat and this often depends on the severity of the symptoms. For example, a woman with mild pain might wish to try conservative treatments such as TENS machine, or exercise for pain relief.
If the condition is more advanced, medication would be required to reduce the unwanted tissue growth, or laparoscopic surgery to remove it.
In severe cases, bowel resection may be required to remove damaged parts of the intestine, hysterectomy (removal of the womb) or oopherectomy (removal of the ovaries). These are treatments which involve significant recovery and ongoing hormonal treatment however, due to the nature of these procedures, it can take 4-8 weeks to recover.
If the unwanted tissue growth of Endometriosis can be inhibited, the likelihood of these more severe treatments being needed will be reduced. However, to qualify for the new Linzagolix therapy patients will need to demonstrate that they have tried other methods first, and many are unsuitable for someone who may want to become pregnant.
Further Information
Find out more about the symptoms and existing treatments of Endometriosis via our website. you can also read some incredible patient stories from women who have shared their healthcare journeys from living with this debilitating disease. Read more about Helen’s story, and how she was thought to have IBS until she finally reached a diagnosis or Endometriosis. Anna also shares her story, and how she remains positive about her body.
You can find out more about Linzagolix here.